HIERARCHICAL TWO-STEP FLOATING CATCHMENT AREA (2SFCA) METHOD: MEASURING THE SPATIAL ACCESSIBILITY TO HIERARCHICAL HEALTHCARE FACILITIES IN SHENZHEN, CHINA

Abstract Background Spatial accessibility to healthcare facilities has drawn much attention in health geography.In China, central and local governments have aimed to develop a well-organized hierarchical system of healthcare facilities in recent years.However, few studies have focused on the measurement of healthcare accessibility in a hierarchical

Determination of ballistic performance of an armor solution is a complicated task and evolved significantly with the application of finite element methods (FEM) in this research field.The traditional armor design studies performed with FEM requires sophisticated procedures and intensive computational effort, therefore simpler and accurate numerical

Abstract Background Mutarotases are recently characterized family of enzymes that are involved in the anomeric conversions of monosaccharides.The mammalian fucose mutarotase (FucM) was reported in cultured cells to facilitate fucose utilization and incorporation into protein by glycosylation.However, the role of this enzyme in animal has not been e

Abstract Objective Because it is impossible to know which statistical learning algorithm performs best on a prediction task, it is common to use stacking methods to ensemble individual learners into a more powerful single learner.Stacking algorithms are usually based on linear Blood Pressure - Blood Pressure Units models, which may run into problem

Abstract A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes.However, beige adipocytes quickly transition into white adipocytes upon removing stimuli.Here, we define the critical role of cyclin dependent kinase inhibitor 2A (Cdkn2a) as a molecular pedal for the beige-to-white transition.Beige adipocytes lacki